When considering off-season use of Trenbolone Enanthate, there is something we must keep in mind. Use will help the individual control his body fat, but this does not mean body fat is impossible to gain. You must consume a level of calories above maintenance to truly grow. Thankfully, with Tren you will make better use of each calorie and the metabolic factors will also provide fat gain protection. However, there will still be a cutoff point. The use of Tren in the off-season is not a license to eat like there’s no end in site. You can still gain plenty of body fat if you don’t exercise self-control.
Tibolone has tissue -selective estrogenic effects, with desirable effects in bone , the brain , and the vagina , and lack of undesirable action in the endometrium and breasts .  Its tissue selectivity is the result of metabolism , enzyme modulation (., of estrogen sulfatase and estrogen sulfotransferase ), and receptor modulation that vary in different target tissues, and differs mechanistically from that of selective estrogen receptor modulators (SERMs) such as tamoxifen , which produce their tissue-selectivity via means of modulation of the ER.   As such, to distinguish it from SERMs, tibolone has been described as a "selective tissue estrogenic activity regulator" (STEAR),  and also as a "selective estrogen enzyme modulator" (SEEM).