Initial damage to the endothelium results in an inflammatory response. Monocytes enter the artery wall from the bloodstream, with platelets adhering to the area of insult. This may be promoted by redox signaling induction of factors such as VCAM-1 , which recruit circulating monocytes, and M-CSF , which is selectively required for the differentiation of monocytes to macrophages. The monocytes differentiate into macrophages , which ingest oxidized LDL, slowly turning into large "foam cells" – so-called because of their changed appearance resulting from the numerous internal cytoplasmic vesicles and resulting high lipid content. Under the microscope, the lesion now appears as a fatty streak. Foam cells eventually die and further propagate the inflammatory process.
In order to provide you with best quality on the market, we are dedicated to keeping up with all new innovations of raw material quality assurance, drug synthesis, and the final packaging of our products. In our laboratories we employ chromatographs of the latest generation which allow us to develop our own base reference of standard drugs. Each and every time we acquire a raw material, it undergoes comparison with the standard and only then is it approved for manufacture. We provide you with raw materials with a purity of at least %!