Dienogest was synthesized in 1979 in Jena , Germany under the leadership of Prof. Kurt Ponsold, was initially referred to as STS-557 .   It was found that its potency was 10 times that of levonorgestrel .  The first product on the market to contain dienogest was a combined oral contraceptive pill (with ethinylestradiol), Valette , introduced in 1995 and made by Jenapharm .  In 2007, dienogest was introduced as Dinagest in Japan for the treatment of endometriosis, and it was subsequently marketed for this indication as Visanne in Europe and Australia in December 2009 and April 2010, respectively.  Qlaira was introduced in Europe in 2009 and Natazia was introduced in the United States in 2010. 
PHARMA MIX M 300 is a blend of two drostanolone esters: propionate and enanthate. It is designed to provide a fast yet extended release of drostanolone. This blend is perfect for long cycles to ensure high quality lean muscle bulk and dense look without excess subcutaneous water retention typical found with long esters. It combines well with testosterone and trenbolone blends (PHARMASUST 300, 500, PHARMA 3 TREN) and long testosterone and trenbolone esters (PHARMATEST E 300, E 500, C 250; PHARMATREN E 200, H 100). A similar stack is implemented in our last development – PHARMA MIX 6, which has already earned a total sales success similarly to PHARMA MIX 2.