Noxious input to the spinal cord is known to produce central sensitization, which consists of allodynia , exaggeration of pain, and punctuate hyperalgesia , extreme sensitivity to pain. Two types of mechanical hyperalgesia can occur: 1) touch that is normally painless in the uninjured surroundings of a cut or tear can trigger painful sensations (touch-evoked hyperalgesia), and 2) a slightly painful pin prick stimulation is perceived as more painful around a focused area of inflammation (punctuate hyperalgesia). Touch-evoked hyperalgesia requires continuous firing of primary afferent nociceptors, and punctuate hyperalgesia does not require continuous firing which means it can persist for hours after a trauma and can be stronger than normally experienced. In addition, it was found that patients with neuropathic pain, histamine ionophoresis resulted in a sensation of burning pain rather than itch, which would be induced in normal healthy patients. This shows that there is spinal hypersensitivity to C-fiber input in chronic pain. 
One study appeared to show that gw 50156 side effects included the growth of cancer cells but on further inspection, the results could be considered misleading. The study of gw1516 which was carried out on mice included 1000 times the recommended dose, taken over a prolonged period of time. As no individual would be taking such an inflated level of gw501516, there is debatable value attached to this particular study. Nevertheless, despite the criticism of this study, it was sufficient for GSK to drop the project so shouldn’t be dismissed completely.
Winstrol is a brand name of the synthetic anabolic steroid, stanozolol. Although no longer available in the . under the name of Winstrol, generic versions of stanozolol can still be found. Stanozolol is similar to testosterone and commonly used by veterinarians on debilitated animals (especially dogs and horses) to improve muscle growth, trigger red blood cell production, increase bone density and enhance appetite. It's approved by the . Food and Drug Administration (FDA) for treating anemia and hereditary angioedema (swelling of blood vessels) in people, although a prescription is needed. Winstrol (stanozolol) is a banned performance-enhancing drug, but still used widely by track and field athletes as well as bodybuilders — usually illegally. You should take stanozolol only with the permission and under the care of a physician.